human EPAS1 shRNA silencing Adenovirus

Product Info

Knockdown

>90% knockdown of mRNA in cultured cells

Viral Details

Viral Backbone

Human Adenovirus Type5 (dE1/E3)

Promoter

U6

Reporter

eGFP (default), optional CFP, YFP, RFP, mCherry

Storage Buffer

DMEM, 2% BSA, 2.5% Glycerol

Gene Details

Species

Human

Gene Symbol

EPAS1

Gene Name

endothelial PAS domain protein 1

Gene ID

2034

Gene Synonyms

bHLHe73; ECYT4; HIF2A; HLF; MOP2; PASD2

ORF Size

2613 bp

RefSeq#

NM_001430

Gene Description

EPAS1 encodes a transcription factor involved in the induction of genes regulated by oxygen, which is induced as oxygen levels fall. The encoded protein contains a basic-helix-loop-helix domain protein dimerization domain as well as a domain found in proteins in signal transduction pathways which respond to oxygen levels. Mutations in this gene are associated with erythrocytosis familial type 4.

UniGene ID

Hs.468410

HGNC ID

HGNC:3374