human EGLN2 shRNA silencing Adenovirus

Product Info

Knockdown

>90% knockdown of mRNA in cultured cells

Viral Details

Viral Backbone

Human Adenovirus Type5 (dE1/E3)

Promoter

U6

Reporter

eGFP (default), optional CFP, YFP, RFP, mCherry

Storage Buffer

DMEM, 2% BSA, 2.5% Glycerol

Gene Details

Species

Human

Gene Symbol

EGLN2

Gene Name

egl-9 family hypoxia inducible factor 2

Gene ID

112398

Gene Synonyms

EIT6; HIF-PH1; HIFPH1; HPH-1; HPH-3; PHD1

ORF Size

1224 bp

RefSeq#

NM_080732

Gene Description

The hypoxia inducible factor (HIF) is a transcriptional complex that is involved in oxygen homeostasis. At normal oxygen levels, the alpha subunit of HIF is targeted for degration by prolyl hydroxylation. This gene encodes an enzyme responsible for this post-translational modification. Alternative splicing results in multiple transcript variants. Read-through transcription also exists between this gene and the upstream RAB4B (RAB4B, member RAS oncogene family) gene.

UniGene ID

Hs.515417

HGNC ID

HGNC:14660