human DNAJC2 shRNA silencing Adenovirus

Product Info

Knockdown

>80% knockdown of mRNA in cultured cells

Viral Details

Viral Backbone

Human Adenovirus Type5 (dE1/E3)

Promoter

U6

Reporter

eGFP (default), optional CFP, YFP, RFP, mCherry

Storage Buffer

DMEM, 2% BSA, 2.5% Glycerol

Gene Details

Species

Human

Gene Symbol

DNAJC2

Gene Name

DnaJ heat shock protein family (Hsp40) member C2

Gene ID

27000

Gene Synonyms

MPHOSPH11; MPP11; ZRF1; ZUO1

ORF Size

1866 bp

RefSeq#

NM_001129887

Gene Description

DNAJC2 is a member of the M-phase phosphoprotein (MPP) family. The gene encodes a phosphoprotein with a J domain and a Myb DNA-binding domain which localizes to both the nucleus and the cytosol. The protein is capable of forming a heterodimeric complex that associates with ribosomes, acting as a molecular chaperone for nascent polypeptide chains as they exit the ribosome. This protein was identified as a leukemia-associated antigen and expression of the gene is upregulated in leukemic blasts. Also, chromosomal aberrations involving this gene are associated with primary head and neck squamous cell tumors. DNAJC2 has a pseudogene on chromosome 6. Alternatively spliced variants which encode different protein isoforms have been described.

UniGene ID

Hs.558476

HGNC ID

HGNC:13192