human CHAT shRNA silencing Adenovirus

Product Info

Knockdown

shRNA screening service available, please inquire about this service or other options.

Viral Details

Viral Backbone

Human Adenovirus Type5 (dE1/E3)

Promoter

U6

Reporter

eGFP (default), optional CFP, YFP, RFP, mCherry

Storage Buffer

DMEM, 2% BSA, 2.5% Glycerol

Gene Details

Species

Human

Gene Symbol

CHAT

Gene Name

choline O-acetyltransferase

Gene ID

1103

Gene Synonyms

CHOACTASE; CMS1A; CMS1A2; CMS6

ORF Size

1893 bp

RefSeq#

NM_020549

Gene Description

CHAT encodes an enzyme which catalyzes the biosynthesis of the neurotransmitter acetylcholine. CHAT product is a characteristic feature of cholinergic neurons, and changes in these neurons may explain some of the symptoms of Alzheimer's disease. Polymorphisms in this gene have been associated with Alzheimer's disease and mild cognitive impairment. Mutations in this gene are associated with congenital myasthenic syndrome associated with episodic apnea. Multiple transcript variants encoding different isoforms have been found for this gene, and some of these variants have been shown to encode more than one isoform.

UniGene ID

Hs.302002

HGNC ID

HGNC:1912