human CASR shRNA silencing Adenovirus
This is an Adenovirus expressing shRNA for silencing of Human CASR.
shADV-204131
Ad-h-CASR-shRNA
Ready-to-use Adenovirus expressing shRNA for silencing of Human CASR (calcium sensing receptor). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
CAR; EIG8; FHH; FIH; GPRC2A; HHC; HHC1; HYPOC1; NSHPT; PCAR1
Description (Vector)
CASR is a G protein-coupled receptor that is expressed in the parathyroid hormone (PTH)-producing chief cells of the parathyroid gland, and the cells lining the kidney tubule. It senses small changes in circulating calcium concentration and couples this information to intracellular signaling pathways that modify PTH secretion or renal cation handling, thus this protein plays an essential role in maintaining mineral ion homeostasis. Mutations in this gene cause familial hypocalciuric hypercalcemia, familial, isolated hypoparathyroidism, and neonatal severe primary hyperparathyroidism.
Gene ID
846
Gene Name (Vector)
calcium sensing receptor
Gene Symbol
CASR
HGNC ID
HGNC:1514
ORF Size (aa)
3237
ORF Size (bp)
3237 bp
RefSeq ID
NM_000388
RefSeq Synonyms
NM_001178065, NM_000388, BC112236, BC104999,
Species
human
UniGene ID
Hs.435615
About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.