human CARD8 shRNA silencing Adenovirus
Category: Adenovirus > shRNA-Silencing
Cat. No: shADV-204088
Availability:
3-5 weeks
Name:
Ad-h-CARD8-shRNA
This is an Adenovirus expressing shRNA for silencing of Human CARD8.
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Product Info
- Knockdown
- >70% knockdown of mRNA in cultured cells
Viral Details
- Viral Backbone
- Human Adenovirus Type5 (dE1/E3)
- Promoter
- U6
- Reporter
- eGFP (default), optional CFP, YFP, RFP, mCherry
- Storage Buffer
- DMEM, 2% BSA, 2.5% Glycerol
Gene Details
- Species
- Human
- Gene Symbol
- CARD8
- Gene Name
- caspase recruitment domain family member 8
- Gene ID
- 22900
- Gene Synonyms
- CARDINAL; DACAR; DAKAR; NDPP; NDPP1; TUCAN
- ORF Size
- 1464 bp
- RefSeq#
- NM_014959
- Gene Description
- CARD8 belongs to the caspase recruitment domain (CARD)-containing family of proteins, which are involved in pathways leading to activation of caspases or nuclear factor kappa-B (NFKB). This protein may be a component of the inflammasome, a protein complex that plays a role in the activation of proinflammatory caspases. It is thought that this protein acts as an adaptor molecule that negatively regulates NFKB activation, CASP1-dependent IL1B secretion, and apoptosis. Polymorphisms in this gene may be associated with a susceptibility to rheumatoid arthritis. Alternatively spliced transcript variants have been described for this gene.
- UniGene ID
- Hs.655940
- HGNC ID
- HGNC:17057
Related Products
Product | Cat No. |
---|---|
AAV-h-CARD8 | AAV-204087 |
AAV-h-CARD8 | AAV-204088 |
Ad-h-CARD8 | ADV-204087 |
Ad-h-CARD8 | ADV-204088 |
AAV-h-CARD8-shRNA | shAAV-204088 |
Control Products
Product | Cat No. |
---|---|
Ad-GFP-U6-shRNA | 1122 |
Ad-U6-Luc-RNAi | 1123 |
Ad-U6-RNAi | 1640 |
Ad-U6-shRNA-CFP | 1780 |
Ad-U6-shRNA-mCherry | 1781 |
Ad-U6-shRNA-RFP | 1782 |
Ad-U6-shRNA-YFP | 1783 |
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