human APPL1 shRNA silencing Adenovirus

Product Info

Knockdown

>90% knockdown of mRNA in cultured cells

Viral Details

Viral Backbone

Human Adenovirus Type5 (dE1/E3)

Promoter

U6

Reporter

eGFP (default), optional CFP, YFP, RFP, mCherry

Storage Buffer

DMEM, 2% BSA, 2.5% Glycerol

Gene Details

Species

Human

Gene Symbol

APPL1

Gene Name

adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 1

Gene ID

26060

Gene Synonyms

APPL; DIP13alpha; MODY14

ORF Size

2130 bp

RefSeq#

NM_012096

Gene Description

APPL1 has been shown to be involved in the regulation of cell proliferation, and in the crosstalk between the adiponectin signalling and insulin signalling pathways. The encoded protein binds many other proteins, including RAB5A, DCC, AKT2, PIK3CA, adiponectin receptors, and proteins of the NuRD/MeCP1 complex. This protein is found associated with endosomal membranes, but can be released by EGF and translocated to the nucleus.

UniGene ID

Hs.476415

HGNC ID

HGNC:24035