human AP4B1 shRNA silencing Adenovirus

Product Info

Knockdown

>60% knockdown of mRNA in cultured cells

Viral Details

Viral Backbone

Human Adenovirus Type5 (dE1/E3)

Promoter

U6

Reporter

eGFP (default), optional CFP, YFP, RFP, mCherry

Storage Buffer

DMEM, 2% BSA, 2.5% Glycerol

Gene Details

Species

Human

Gene Symbol

AP4B1

Gene Name

adaptor related protein complex 4 beta 1 subunit

Gene ID

10717

Gene Synonyms

BETA-4; CPSQ5; SPG47

ORF Size

2220 bp

RefSeq#

NM_006594

Gene Description

AP4B1 encodes a subunit of a heterotetrameric adapter-like complex 4 that is involved in targeting proteins from the trans-Golgi network to the endosomal-lysosomal system. Mutations in this gene are associated with cerebral palsy spastic quadriplegic type 5 (CPSQ5) disorder. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.

UniGene ID

Hs.515048

HGNC ID

HGNC:572