human ANKS1B shRNA silencing Adenovirus

Product Info

Knockdown

shRNA screening service available, please inquire about this service or other options.

Viral Details

Viral Backbone

Human Adenovirus Type5 (dE1/E3)

Promoter

U6

Reporter

eGFP (default), optional CFP, YFP, RFP, mCherry

Storage Buffer

DMEM, 2% BSA, 2.5% Glycerol

Gene Details

Species

Human

Gene Symbol

ANKS1B

Gene Name

ankyrin repeat and sterile alpha motif domain containing 1B

Gene ID

56899

Gene Synonyms

AIDA; AIDA-1; ANKS2; cajalin-2; EB-1; EB1

ORF Size

3747 bp

RefSeq#

NM_020140

Gene Description

ANKS1B encodes a multi-domain protein that is predominantly expressed in brain and testis. This protein interacts with amyloid beta protein precursor (AbetaPP) and may have a role in normal brain development, and in the pathogenesis of Alzheimer's disease. Expression of this gene has been shown to be elevated in patients with pre-B cell acute lymphocytic leukemia associated with t(1;19) translocation. Alternatively spliced transcript variants encoding different isoforms (some with different subcellular localization, PMID:15004329) have been described for this gene.

UniGene ID

Hs.506458

HGNC ID

HGNC:24600