rat PACRG shRNA silencing AAV

Cat. No: shAAV-295129

Availability: 6-8 weeks

Name: AAV-r-PACRG-shRNA

This is an AAV expressing shRNA for silencing of Rat Pacrg.

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Knockdown: shRNA screening service available, please inquire about this service or other options.

Viral Backbone: Recombinant AAV
AAV-ITR: AAV2
AAV Serotype: Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
Promoter: U6
Reporter: eGFP (default), optional CFP, YFP, RFP, mCherry
Storage Buffer: PBS/5% Glycerol

Species: Rat
Gene Symbol: Pacrg
Gene Name: Park2 co-regulated
Gene ID: 499021
Gene Synonyms: RGD1561027
ORF Size: 909 bp
RefSeq#: NM_001077677
Gene Description: Suppresses cell death induced by accumulation of unfolded Pael receptor (Pael-R, a substrate of Parkin). Facilitates the formation of inclusions consisting of Pael-R, molecular chaperones, protein degradation molecules and itself when proteasome is inhibited. May play an important role in the formation of Lewy bodies and protection of dopaminergic neurons against Parkinson disease.