rat NAE1 shRNA silencing AAV

Cat. No: shAAV-295076

Availability: 4-5 weeks

Name: AAV-r-NAE1-shRNA

This is an AAV expressing shRNA for silencing of Rat Nae1.

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Viral Backbone: Recombinant AAV
AAV-ITR: AAV2
AAV Serotype: Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
Promoter: U6
Reporter: eGFP (default), optional CFP, YFP, RFP, mCherry
Storage Buffer: PBS/5% Glycerol

Species: Rat
Gene Symbol: Nae1
Gene Name: NEDD8 activating enzyme E1 subunit 1
Gene ID: 84019
Gene Synonyms: Appbp1; RGD1563180
ORF Size: 1605 bp
RefSeq#: NM_032072
Gene Description: Regulatory subunit of the dimeric UBA3-NAE1 E1 enzyme. E1 activates NEDD8 by first adenylating its C-terminal glycine residue with ATP, thereafter linking this residue to the side chain of the catalytic cysteine, yielding a NEDD8-UBA3 thioester and free AMP. E1 finally transfers NEDD8 to the catalytic cysteine of UBE2M. Necessary for cell cycle progression through the S-M checkpoint. Overexpression of NAE1 causes apoptosis through deregulation of NEDD8 conjugation.