rat A2M shRNA silencing AAV

Cat. No: shAAV-294270

Availability: 6-8 weeks

Name: AAV-r-A2M-shRNA

This is an AAV expressing shRNA for silencing of Rat A2m.

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Knockdown: shRNA screening service available, please inquire about this service or other options.

Viral Backbone: Recombinant AAV
AAV-ITR: AAV2
AAV Serotype: Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
Promoter: U6
Reporter: eGFP (default), optional CFP, YFP, RFP, mCherry
Storage Buffer: PBS/5% Glycerol

Species: Rat
Gene Symbol: A2m
Gene Name: alpha-2-macroglobulin
Gene ID: 24153
Gene Synonyms: A2m1; A2maa; A2MAC1; A2mb; Mam
ORF Size: 4419 bp
RefSeq#: NM_012488
Gene Description: Is able to inhibit all four classes of proteinases by a unique 'trapping' mechanism. This protein has a peptide stretch, called the 'bait region' which contains specific cleavage sites for different proteinases. When a proteinase cleaves the bait region, a conformational change is induced in the protein which traps the proteinase. The entrapped enzyme remains active against low molecular weight substrates (activity against high molecular weight substrates is greatly reduced). Following cleavage in the bait region a thioester bond is hydrolyzed and mediates the covalent binding of the protein to the proteinase.