rat ATG4B shRNA silencing AAV

Cat. No: shAAV-294229

Availability: 4-5 weeks

Name: AAV-r-ATG4B-shRNA

This is an AAV expressing shRNA for silencing of Rat Atg4b.

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Viral Backbone: Recombinant AAV
AAV-ITR: AAV2
AAV Serotype: Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
Promoter: U6
Reporter: eGFP (default), optional CFP, YFP, RFP, mCherry
Storage Buffer: PBS/5% Glycerol

Species: Rat
Gene Symbol: Atg4b
Gene Name: autophagy related 4B, cysteine peptidase
Gene ID: 316640
Gene Synonyms: Apg4b
ORF Size: 675 bp
RefSeq#: NM_001025711
Gene Description: Cysteine protease required for autophagy, which cleaves the C-terminal part of either MAP1LC3, GABARAPL2 or GABARAP, allowing the liberation of form I. A subpopulation of form I is subsequently converted to a smaller form (form II). Form II, with a revealed C-terminal glycine, is considered to be the phosphatidylethanolamine (PE)-conjugated form, and has the capacity for the binding to autophagosomes.