rat H2AFZ shRNA silencing AAV

Cat. No: shAAV-293841

Availability: 4-5 weeks

Name: AAV-r-H2AFZ-shRNA

This is an AAV expressing shRNA for silencing of Rat H2afz.

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Viral Backbone: Recombinant AAV
AAV-ITR: AAV2
AAV Serotype: Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
Promoter: U6
Reporter: eGFP (default), optional CFP, YFP, RFP, mCherry
Storage Buffer: PBS/5% Glycerol

Species: Rat
Gene Symbol: H2afz
Gene Name: H2A histone family, member Z
Gene ID: 58940
Gene Synonyms: H2A.Z-1
ORF Size: 387 bp
RefSeq#: NM_022674
Gene Description: Variant histone H2A which replaces conventional H2A in a subset of nucleosomes. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. May be involved in the formation of constitutive heterochromatin. May be required for chromosome segregation during cell division.