rat GRB2 shRNA silencing AAV

Cat. No: shAAV-293317

Availability: 4-5 weeks

Name: AAV-r-GRB2-shRNA

This is an AAV expressing shRNA for silencing of Rat Grb2.

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Viral Backbone: Recombinant AAV
AAV-ITR: AAV2
AAV Serotype: Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
Promoter: U6
Reporter: eGFP (default), optional CFP, YFP, RFP, mCherry
Storage Buffer: PBS/5% Glycerol

Species: Rat
Gene Symbol: Grb2
Gene Name: growth factor receptor bound protein 2
Gene ID: 81504
Gene Synonyms: Ash-psi
ORF Size: 654 bp
RefSeq#: NM_030846
Gene Description: Adapter protein that provides a critical link between cell surface growth factor receptors and the Ras signaling pathway|Function: Isoform 2 does not bind to phosphorylated epidermal growth factor receptor (EGFR) but inhibits EGF-induced transactivation of a RAS-responsive element. Isoform 2 acts as a dominant negative protein over GRB2 and by suppressing proliferative signals, may trigger active programmed cell death.