rat NR1H3 shRNA silencing AAV

Cat. No: shAAV-293107

Availability: 6-8 weeks

Name: AAV-r-NR1H3-shRNA

This is an AAV expressing shRNA for silencing of Rat Nr1h3.

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Knockdown: shRNA screening service available, please inquire about this service or other options.

Viral Backbone: Recombinant AAV
AAV-ITR: AAV2
AAV Serotype: Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
Promoter: U6
Reporter: eGFP (default), optional CFP, YFP, RFP, mCherry
Storage Buffer: PBS/5% Glycerol

Species: Rat
Gene Symbol: Nr1h3
Gene Name: nuclear receptor subfamily 1, group H, member 3
Gene ID: 58852
Gene Synonyms: LXRalpha
ORF Size: 1338 bp
RefSeq#: NM_031627
Gene Description: Orphan receptor. Interaction with RXR shifts RXR from its role as a silent DNA-binding partner to an active ligand-binding subunit in mediating retinoid responses through target genes defined by LXRES. LXRES are DR4-type response elements characterized by direct repeats of two similar hexanuclotide half-sites spaced by four nucleotides. Plays an important role in the regulation of cholesterol homeostasis, regulating cholesterol uptake through MYLIP-dependent ubiquitination of LDLR, VLDLR and LRP8 (By similarity).