rat NLRX1 shRNA silencing AAV

Cat. No: shAAV-292824

Availability: 6-8 weeks

Name: AAV-r-NLRX1-shRNA

This is an AAV expressing shRNA for silencing of Rat Nlrx1.

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Knockdown: shRNA screening service available, please inquire about this service or other options.

Viral Backbone: Recombinant AAV
AAV-ITR: AAV2
AAV Serotype: Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
Promoter: U6
Reporter: eGFP (default), optional CFP, YFP, RFP, mCherry
Storage Buffer: PBS/5% Glycerol

Species: Rat
Gene Symbol: Nlrx1
Gene Name: NLR family member X1
Gene ID: 315599
Gene Synonyms: RGD1311293
ORF Size: 2922 bp
RefSeq#: NM_001025010
Gene Description: Participates in antiviral signaling. Acts as a negative regulator of MAVS-mediated antiviral responses, through the inhibition of the virus-induced RLH (RIG-like helicase)-MAVS interaction (PubMed:18200010). Has no inhibitory function on NF-Kappa-B and type 1 interferon signaling pathways, but enhances NF-Kappa-B and JUN N-terminal kinase dependent signaling through the production of reactive oxygen species (PubMed:18219313).