rat DNM1L shRNA silencing AAV

Cat. No: shAAV-292343

Availability: 4-5 weeks

Name: AAV-r-DNM1L-shRNA

This is an AAV expressing shRNA for silencing of Rat Dnm1l.

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Viral Backbone: Recombinant AAV
AAV-ITR: AAV2
AAV Serotype: Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
Promoter: U6
Reporter: eGFP (default), optional CFP, YFP, RFP, mCherry
Storage Buffer: PBS/5% Glycerol

Species: Rat
Gene Symbol: Dnm1l
Gene Name: dynamin 1-like
Gene ID: 114114
Gene Synonyms: DLP1; Dnml1; Drp1
ORF Size: 2151 bp
RefSeq#: NM_053655
Gene Description: Functions in mitochondrial and peroxisomal division. Mediates membrane fission through oligomerization into ring-like structures which wrap around the scission site to constict and sever the mitochondrial membrane through a GTP hydrolysis-dependent mechanism. Required for normal brain development. Facilitates developmentally-regulated apoptosis during neural tube development. Required for a normal rate of cytochrome c release and caspase activation during apoptosis. Also required for mitochondrial fission during mitosis. May be involved in vesicle transport|Function: Isoform 1 and isoform 4 inhibit peroxisomal division when overexpressed.