rat HOPX shRNA silencing AAV

Cat. No: shAAV-292117

Availability: 4-5 weeks

Name: AAV-r-HOPX-shRNA

This is an AAV expressing shRNA for silencing of Rat Hopx.

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Viral Backbone: Recombinant AAV
AAV-ITR: AAV2
AAV Serotype: Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
Promoter: U6
Reporter: eGFP (default), optional CFP, YFP, RFP, mCherry
Storage Buffer: PBS/5% Glycerol

Species: Rat
Gene Symbol: Hopx
Gene Name: HOP homeobox
Gene ID: 171160
Gene Synonyms: GIIg15b; Hod; Obl
ORF Size: 222 bp
RefSeq#: NM_133621
Gene Description: Atypical homeodomain protein which does not bind DNA and is required to modulate cardiac growth and development. Acts via its interaction with SRF, thereby modulating the expression of SRF-dependent cardiac-specific genes and cardiac development. Prevents SRF-dependent transcription either by inhibiting SRF binding to DNA or by recruiting histone deacetylase (HDAC) proteins that prevent transcription by SRF. Overexpression causes cardiac hypertrophy (By similarity). May act as a tumor suppressor.