rat RGD1310414 shRNA silencing AAV

Cat. No: shAAV-290799

Availability: 6-8 weeks

Name: AAV-r-RGD1310414-shRNA

This is an AAV expressing shRNA for silencing of Rat Tti2.

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Knockdown: shRNA screening service available, please inquire about this service or other options.

Viral Backbone: Recombinant AAV
AAV-ITR: AAV2
AAV Serotype: Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
Promoter: U6
Reporter: eGFP (default), optional CFP, YFP, RFP, mCherry
Storage Buffer: PBS/5% Glycerol

Species: Rat
Gene Symbol: Tti2
Gene Name: TELO2 interacting protein 2
Gene ID: 290811
Gene Synonyms: RGD1310414
ORF Size: 1536 bp
RefSeq#: NM_001013883
Gene Description: Regulator of the DNA damage response (DDR). Part of the TTT complex that is required to stabilize protein levels of the phosphatidylinositol 3-kinase-related protein kinase (PIKK) family proteins. The TTT complex is involved in the cellular resistance to DNA damage stresses, like ionizing radiation (IR), ultraviolet (UV) and mitomycin C (MMC). Together with the TTT complex and HSP90 may participate in the proper folding of newly synthesized PIKKs.