rat CASQ2 shRNA silencing AAV

Cat. No: shAAV-290603

Availability: 6-8 weeks

Name: AAV-r-CASQ2-shRNA

This is an AAV expressing shRNA for silencing of Rat Casq2.

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Knockdown: shRNA screening service available, please inquire about this service or other options.

Viral Backbone: Recombinant AAV
AAV-ITR: AAV2
AAV Serotype: Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
Promoter: U6
Reporter: eGFP (default), optional CFP, YFP, RFP, mCherry
Storage Buffer: PBS/5% Glycerol

Species: Rat
Gene Symbol: Casq2
Gene Name: calsequestrin 2
Gene ID: 29209
Gene Synonyms: cardCSQ
ORF Size: 1284 bp
RefSeq#: NM_017131
Gene Description: Calsequestrin is a high-capacity, moderate affinity, calcium-binding protein and thus acts as an internal calcium store in muscle. The release of calcium bound to calsequestrin through a calcium release channel triggers muscle contraction. The skeletal muscle isoform (CASQ1) binds around 80 Ca(2+) ions, while the cardiac isoform (CASQ2) binds approximately 60 Ca(2+) ions.