rat KHDRBS1 shRNA silencing AAV

Cat. No: shAAV-290566

Availability: 4-5 weeks

Name: AAV-r-KHDRBS1-shRNA

This is an AAV expressing shRNA for silencing of Rat Khdrbs1.

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Viral Backbone: Recombinant AAV
AAV-ITR: AAV2
AAV Serotype: Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
Promoter: U6
Reporter: eGFP (default), optional CFP, YFP, RFP, mCherry
Storage Buffer: PBS/5% Glycerol

Species: Rat
Gene Symbol: Khdrbs1
Gene Name: KH RNA binding domain containing, signal transduction associated 1
Gene ID: 117268
Gene Synonyms: P62; Sam68
ORF Size: 1332 bp
RefSeq#: NM_130405
Gene Description: Recruited and tyrosine phosphorylated by several receptor systems, for example the T-cell, leptin and insulin receptors. Once phosphorylated, functions as an adapter protein in signal transduction cascades by binding to SH2 and SH3 domain-containing proteins. Role in G2-M progression in the cell cycle. Represses CBP-dependent transcriptional activation apparently by competing with other nuclear factors for binding to CBP. Also acts as a putative regulator of mRNA stability and/or translation rates and mediates mRNA nuclear export|Function: Isoform 3, which is expressed in growth-arrested cells only, inhibits S phase.