rat HSD17B12 shRNA silencing AAV

Cat. No: shAAV-290106

Availability: 4-5 weeks

Name: AAV-r-HSD17B12-shRNA

This is an AAV expressing shRNA for silencing of Rat Hsd17b12.

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Viral Backbone: Recombinant AAV
AAV-ITR: AAV2
AAV Serotype: Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
Promoter: U6
Reporter: eGFP (default), optional CFP, YFP, RFP, mCherry
Storage Buffer: PBS/5% Glycerol

Species: Rat
Gene Symbol: Hsd17b12
Gene Name: hydroxysteroid (17-beta) dehydrogenase 12
Gene ID: 84013
ORF Size: 939 bp
RefSeq#: NM_032066
Gene Description: Catalyzes the transformation of estrone (E1) into estradiol (E2), suggesting a central role in estrogen formation. Its strong expression in ovary and mammary gland suggest that it may constitute the major enzyme responsible for the conversion of E1 to E2 in women. Also has 3-ketoacyl-CoA reductase activity, reducing both long chain 3-ketoacyl-CoAs and long chain fatty acyl-CoAs, suggesting a role in long fatty acid elongation.