mouse MASTL shRNA silencing AAV
Category: AAV > shRNA-Silencing
Cat. No: shAAV-280876
Availability:
6-8 weeks
Name:
AAV-m-MASTL-shRNA
This is an AAV expressing shRNA for silencing of Mouse Mastl.
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Product Info
- Knockdown
- shRNA screening service available, please inquire about this service or other options.
Viral Details
- Viral Backbone
- Recombinant AAV
- AAV-ITR
- AAV2
- AAV Serotype
- Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
- Promoter
- U6
- Reporter
- eGFP (default), optional CFP, YFP, RFP, mCherry
- Storage Buffer
- PBS/5% Glycerol
Gene Details
- Species
- Mouse
- Gene Symbol
- Mastl
- Gene Name
- microtubule associated serine/threonine kinase-like
- Gene ID
- 67121
- Gene Synonyms
- 2700091H24Rik; C88295; GW; GWL; MAST-L; THC2
- ORF Size
- 2598 bp
- RefSeq#
- NM_025979
- Gene Description
- Serine/threonine kinase that plays a key role in M phase by acting as a regulator of mitosis entry and maintenance. Acts by promoting the inactivation of protein phosphatase 2A (PP2A) during M phase: does not directly inhibit PP2A but acts by mediating phosphorylation and subsequent activation of ARPP19 and ENSA at 'Ser-62' and 'Ser-67', respectively. ARPP19 and ENSA are phosphatase inhibitors that specifically inhibit the PPP2R2D (PR55-delta) subunit of PP2A. Inactivation of PP2A during M phase is essential to keep cyclin-B1-CDK1 activity high. Following DNA damage, it is also involved in checkpoint recovery by being inhibited. Phosphorylates histone protein in vitro; however such activity is unsure in vivo. May be involved in megakaryocyte differentiation.
- UniGene ID
- Mm.253721
Related Products
Product | Cat No. |
---|---|
AAV-h-MASTL | AAV-215061 |
AAV-m-MASTL | AAV-280876 |
Ad-h-MASTL | ADV-215061 |
Ad-m-MASTL | ADV-280876 |
AAV-h-MASTL-shRNA | shAAV-215061 |
Ad-h-MASTL-shRNA | shADV-215061 |
Ad-m-MASTL-shRNA | shADV-280876 |
Control Products
Product | Cat No. |
---|---|
AAV1-GFP-U6-shRNA | 7040 |
AAV2-GFP-U6-shRNA | 7041 |
AAV5-GFP-U6-shRNA | 7042 |
AAV6-GFP-U6-shRNA | 7043 |
AAV9-GFP-U6-shRNA | 7045 |
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