mouse DKK1 shRNA silencing AAV

Cat. No: shAAV-280686

Availability: Immediate

Name: AAV-m-DKK1-shRNA

This is an AAV expressing shRNA for silencing of Mouse Dkk1.

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Viral Backbone: Recombinant AAV
AAV-ITR: AAV2
AAV Serotype: Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
Promoter: U6
Reporter: eGFP (default), optional CFP, YFP, RFP, mCherry
Storage Buffer: PBS/5% Glycerol

Species: Mouse
Gene Symbol: Dkk1
Gene Name: dickkopf WNT signaling pathway inhibitor 1
Gene ID: 13380
Gene Synonyms: mdkk-1
ORF Size: 819 bp
RefSeq#: NM_010051
Gene Description: Antagonizes canonical Wnt signaling by inhibiting LRP5/6 interaction with Wnt and by forming a ternary complex with the transmembrane protein KREMEN that promotes internalization of LRP5/6. DKKs play an important role in vertebrate development, where they locally inhibit Wnt regulated processes such as antero-posterior axial patterning, limb development, somitogenesis and eye formation. In the adult, Dkks are implicated in bone formation and bone disease, cancer and Alzheimer disease.
UniGene ID: Mm.214717