mouse ABCG2 shRNA silencing AAV

Cat. No: shAAV-280528

Availability: 6-8 weeks

Name: AAV-m-ABCG2-shRNA

This is an AAV expressing shRNA for silencing of Mouse Abcg2.

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Knockdown: shRNA screening service available, please inquire about this service or other options.

Viral Backbone: Recombinant AAV
AAV-ITR: AAV2
AAV Serotype: Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
Promoter: U6
Reporter: eGFP (default), optional CFP, YFP, RFP, mCherry
Storage Buffer: PBS/5% Glycerol

Species: Mouse
Gene Symbol: Abcg2
Gene Name: ATP-binding cassette, sub-family G (WHITE), member 2
Gene ID: 26357
Gene Synonyms: ABC15; ABCP; AI428558; BCRP; Bcrp1; MXR; MXR1
ORF Size: 1974 bp
RefSeq#: NM_011920
Gene Description: Xenobiotic transporter that may play an important role in the exclusion of xenobiotics from the brain. May be involved in brain-to-blood efflux. Appears to play a major role in the multidrug resistance phenotype of several cancer cell lines. When overexpressed, the transfected cells become resistant to mitoxantrone, daunorubicin and doxorubicin, display diminished intracellular accumulation of daunorubicin, and manifest an ATP-dependent increase in the efflux of rhodamine 123.
UniGene ID: Mm.333096