mouse DNAJB6 shRNA silencing AAV

Cat. No: shAAV-279172

Availability: 4-5 weeks

Name: AAV-m-DNAJB6-shRNA

This is an AAV expressing shRNA for silencing of Mouse Dnajb6.

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Viral Backbone: Recombinant AAV
AAV-ITR: AAV2
AAV Serotype: Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
Promoter: U6
Reporter: eGFP (default), optional CFP, YFP, RFP, mCherry
Storage Buffer: PBS/5% Glycerol

Species: Mouse
Gene Symbol: Dnajb6
Gene Name: DnaJ heat shock protein family (Hsp40) member B6
Gene ID: 23950
Gene Synonyms: mDj4; Mrj
ORF Size: 729 bp
RefSeq#: NM_011847
Gene Description: Plays an indispensable role in the organization of KRT8/KRT18 filaments. Acts as an endogenous molecular chaperone for neuronal proteins including huntingtin. Suppresses aggregation and toxicity of polyglutamine-containing, aggregation-prone proteins. Isoform B but not isoform A inhibits huntingtin aggregation. Has a stimulatory effect on the ATPase activity of HSP70 in a dose-dependent and time-dependent manner and hence acts as a co-chaperone of HSP70. Also reduces cellular toxicity and caspase-3 activity.
UniGene ID: Mm.290110