mouse SRSF2 shRNA silencing AAV

Cat. No: shAAV-277653

Availability: 4-5 weeks

Name: AAV-m-SRSF2-shRNA

This is an AAV expressing shRNA for silencing of Mouse Srsf2.

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Viral Backbone: Recombinant AAV
AAV-ITR: AAV2
AAV Serotype: Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
Promoter: U6
Reporter: eGFP (default), optional CFP, YFP, RFP, mCherry
Storage Buffer: PBS/5% Glycerol

Species: Mouse
Gene Symbol: Srsf2
Gene Name: serine/arginine-rich splicing factor 2
Gene ID: 20382
Gene Synonyms: D11Wsu175e; MRF-1; Pr264; SC35; Sfrs10; Sfrs2
ORF Size: 666 bp
RefSeq#: NM_011358
Gene Description: Necessary for the splicing of pre-mRNA. It is required for formation of the earliest ATP-dependent splicing complex and interacts with spliceosomal components bound to both the 5'- and 3'-splice sites during spliceosome assembly. It also is required for ATP-dependent interactions of both U1 and U2 snRNPs with pre-mRNA. Interacts with other spliceosomal components, via the RS domains, to form a bridge between the 5'- and 3'-splice site binding components, U1 snRNP and U2AF. Binds to purine-rich RNA sequences, either 5'-AGSAGAGTA-3' (S=C or G) or 5'-GTTCGAGTA-3'. Can bind to beta-globin mRNA and commit it to the splicing pathway. The phosphorylated form (by SRPK2) is required for cellular apoptosis in response to cisplatin treatment.
UniGene ID: Mm.21841