mouse USP37 shRNA silencing AAV

Cat. No: shAAV-277211

Availability: 4-5 weeks

Name: AAV-m-USP37-shRNA

This is an AAV expressing shRNA for silencing of Mouse Usp37.

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Viral Backbone: Recombinant AAV
AAV-ITR: AAV2
AAV Serotype: Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
Promoter: U6
Reporter: eGFP (default), optional CFP, YFP, RFP, mCherry
Storage Buffer: PBS/5% Glycerol

Species: Mouse
Gene Symbol: Usp37
Gene Name: ubiquitin specific peptidase 37
Gene ID: 319651
Gene Synonyms: 4932415L06Rik; C330008N13Rik
ORF Size: 2940 bp
RefSeq#: NM_176972
Gene Description: Deubiquitinase that antagonizes the anaphase-promoting complex (APC/C) during G1/S transition by mediating deubiquitination of cyclin-A (CCNA1 and CCNA2), thereby promoting S phase entry. Specifically mediates deubiquitination of 'Lys-11'-linked polyubiquitin chains, a specific ubiquitin-linkage type mediated by the APC/C complex. Also mediates deubiquitination of 'Lys-48'-linked polyubiquitin chains in vitro. Phosphorylation at Ser-628 during G1/S phase maximizes the deubiquitinase activity, leading to prevent degradation of cyclin-A (CCNA1 and CCNA2).
UniGene ID: Mm.66568