mouse VHL shRNA silencing AAV

Cat. No: shAAV-276007

Availability: 4-5 weeks

Name: AAV-m-VHL-shRNA

This is an AAV expressing shRNA for silencing of Mouse Vhl.

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Viral Backbone: Recombinant AAV
AAV-ITR: AAV2
AAV Serotype: Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
Promoter: U6
Reporter: eGFP (default), optional CFP, YFP, RFP, mCherry
Storage Buffer: PBS/5% Glycerol

Species: Mouse
Gene Symbol: Vhl
Gene Name: von Hippel-Lindau tumor suppressor
Gene ID: 22346
Gene Synonyms: Vhlh
ORF Size: 546 bp
RefSeq#: NM_009507
Gene Description: Involved in the ubiquitination and subsequent proteasomal degradation via the von Hippel-Lindau ubiquitination complex. Seems to act as target recruitment subunit in the E3 ubiquitin ligase complex and recruits hydroxylated hypoxia-inducible factor (HIF) under normoxic conditions. Involved in transcriptional repression through interaction with HIF1A, HIF1AN and histone deacetylases. Ubiquitinates, in an oxygen-responsive manner, ADRB2.
UniGene ID: Mm.29407