mouse UNC13B shRNA silencing AAV

Cat. No: shAAV-275630

Availability: Immediate

Name: AAV-m-UNC13B-shRNA

This is an AAV expressing shRNA for silencing of Mouse Unc13b.

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Viral Backbone: Recombinant AAV
AAV-ITR: AAV2
AAV Serotype: Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
Promoter: U6
Reporter: eGFP (default), optional CFP, YFP, RFP, mCherry
Storage Buffer: PBS/5% Glycerol

Species: Mouse
Gene Symbol: Unc13b
Gene Name: unc-13 homolog B (C. elegans)
Gene ID: 22249
Gene Synonyms: Munc13-1; Munc13-2; Unc13a; Unc13h1; Unc13h2
ORF Size: 4806 bp
RefSeq#: NM_001081413
Gene Description: Plays a role in vesicle maturation during exocytosis as a target of the diacylglycerol second messenger pathway. Is involved in neurotransmitter release by acting in synaptic vesicle priming prior to vesicle fusion and participates in the activity-depending refilling of readily releasable vesicle pool (RRP). Essential for synaptic vesicle maturation in a subset of excitatory/glutamatergic but not inhibitory/GABA-mediated synapses (By similarity).
UniGene ID: Mm.128892