mouse TSC22D3 shRNA silencing AAV

Cat. No: shAAV-275124

Availability: 4-5 weeks

Name: AAV-m-TSC22D3-shRNA

This is an AAV expressing shRNA for silencing of Mouse Tsc22d3.

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Viral Backbone: Recombinant AAV
AAV-ITR: AAV2
AAV Serotype: Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
Promoter: U6
Reporter: eGFP (default), optional CFP, YFP, RFP, mCherry
Storage Buffer: PBS/5% Glycerol

Species: Mouse
Gene Symbol: Tsc22d3
Gene Name: TSC22 domain family, member 3
Gene ID: 14605
Gene Synonyms: DIP; Dsip1; Gilz; Tilz3; TSC-22R
ORF Size: 414 bp
RefSeq#: NM_010286
Gene Description: Protects T-cells from IL2 deprivation-induced apoptosis through the inhibition of FOXO3A transcriptional activity that leads to the down-regulation of the pro-apoptotic factor BCL2L11. In macrophages, plays a role in the anti-inflammatory and immunosuppressive effects of glucocorticoids and IL10. In T-cells, inhibits anti-CD3-induced NFKB1 nuclear translocation. In vitro, suppresses AP1 and NFKB1 DNA-binding activities (By similarity).
UniGene ID: Mm.22216