mouse TSC1 shRNA silencing AAV

Cat. No: shAAV-275119

Availability: 4-5 weeks

Name: AAV-m-TSC1-shRNA

This is an AAV expressing shRNA for silencing of Mouse Tsc1.

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Viral Backbone: Recombinant AAV
AAV-ITR: AAV2
AAV Serotype: Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
Promoter: U6
Reporter: eGFP (default), optional CFP, YFP, RFP, mCherry
Storage Buffer: PBS/5% Glycerol

Species: Mouse
Gene Symbol: Tsc1
Gene Name: tuberous sclerosis 1
Gene ID: 64930
ORF Size: 3447 bp
RefSeq#: NM_022887
Gene Description: In complex with TSC2, inhibits the nutrient-mediated or growth factor-stimulated phosphorylation of S6K1 and EIF4EBP1 by negatively regulating mTORC1 signaling. Seems not to be required for TSC2 GAP activity towards RHEB. Implicated as a tumor suppressor. Involved in microtubule-mediated protein transport, but this seems to be due to unregulated mTOR signaling.
UniGene ID: Mm.224354