mouse TRPV6 shRNA silencing AAV

Cat. No: shAAV-275112

Availability: 6-8 weeks

Name: AAV-m-TRPV6-shRNA

This is an AAV expressing shRNA for silencing of Mouse Trpv6.

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Knockdown: shRNA screening service available, please inquire about this service or other options.

Viral Backbone: Recombinant AAV
AAV-ITR: AAV2
AAV Serotype: Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
Promoter: U6
Reporter: eGFP (default), optional CFP, YFP, RFP, mCherry
Storage Buffer: PBS/5% Glycerol

Species: Mouse
Gene Symbol: Trpv6
Gene Name: transient receptor potential cation channel, subfamily V, member 6
Gene ID: 64177
Gene Synonyms: Cac; CAT; CaT1; Ecac2; Otrpc3
ORF Size: 2184 bp
RefSeq#: NM_022413
Gene Description: Calcium selective cation channel probably involved in Ca(2+) uptake in various tissues, including Ca(2+) reabsorption in intestine. The channel is activated by low internal calcium level, probably including intracellular calcium store depletion, and the current exhibits an inward rectification. Inactivation includes both, a rapid Ca(2+)-dependent and a slower Ca(2+)-calmodulin-dependent mechanism, the latter may be regulated by phosphorylation. In vitro, is slowly inhibited by Mg(2+) in a voltage-independent manner. Heteromeric assembly with TRPV5 seems to modify channel properties. TRPV5-TRPV6 heteromultimeric concatemers exhibit voltage-dependent gating (By similarity).
UniGene ID: Mm.296889