mouse TRPV4 shRNA silencing AAV

Cat. No: shAAV-275109

Availability: 6-8 weeks

Name: AAV-m-TRPV4-shRNA

This is an AAV expressing shRNA for silencing of Mouse Trpv4.

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Viral Backbone: Recombinant AAV
AAV-ITR: AAV2
AAV Serotype: Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
Promoter: U6
Reporter: eGFP (default), optional CFP, YFP, RFP, mCherry
Storage Buffer: PBS/5% Glycerol

Species: Mouse
Gene Symbol: Trpv4
Gene Name: transient receptor potential cation channel, subfamily V, member 4
Gene ID: 63873
Gene Synonyms: 0610033B08Rik; OTRPC4; Trp12; VR-OAC; VRL-2; VROAC
ORF Size: 2616 bp
RefSeq#: NM_022017
Gene Description: Non-selective calcium permeant cation channel probably involved in osmotic sensitivity and mechanosensitivity. Activation by exposure to hypotonicity within the physiological range exhibits an outward rectification. Also activated by low pH, citrate and phorbol esters. Increase of intracellular Ca(2+) potentiates currents. Channel activity seems to be regulated by a calmodulin-dependent mechanism with a negative feedback mechanism. Promotes cell-cell junction formation in skin keratinocytes and plays an important role in the formation and/or maintenance of functional intercellular barriers. Acts as a regulator of intracellular Ca(2+) in synoviocytes. Plays an obligatory role as a molecular component in the nonselective cation channel activation induced by 4-alpha-phorbol 12,13-didecanoate and hypotonic stimulation in synoviocytes and also regulates production of IL-8.
UniGene ID: Mm.266450