mouse C3 shRNA silencing AAV

Cat. No: shAAV-274727

Availability: 4-5 weeks

Name: AAV-m-C3-shRNA

This is an AAV expressing shRNA for silencing of Mouse C3.

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Viral Backbone: Recombinant AAV
AAV-ITR: AAV2
AAV Serotype: Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
Promoter: U6
Reporter: eGFP (default), optional CFP, YFP, RFP, mCherry
Storage Buffer: PBS/5% Glycerol

Species: Mouse
Gene Symbol: C3
Gene Name: complement component 3
Gene ID: 12266
Gene Synonyms: AI255234; ASP; HSE-MSF; Plp
ORF Size: 4992 bp
RefSeq#: NM_009778
Gene Description: C3 plays a central role in the activation of the complement system. Its processing by C3 convertase is the central reaction in both classical and alternative complement pathways. After activation C3b can bind covalently, via its reactive thioester, to cell surface carbohydrates or immune aggregates|Function: Derived from proteolytic degradation of complement C3, C3a anaphylatoxin is a mediator of local inflammatory process. It induces the contraction of smooth muscle, increases vascular permeability and causes histamine release from mast cells and basophilic leukocytes.
UniGene ID: Mm.19131