mouse TNF shRNA silencing AAV

Cat. No: shAAV-274675

Availability: 6-8 weeks

Name: AAV-m-TNF-shRNA

This is an AAV expressing shRNA for silencing of Mouse Tnf.

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Knockdown: shRNA screening service available, please inquire about this service or other options.

Viral Backbone: Recombinant AAV
AAV-ITR: AAV2
AAV Serotype: Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
Promoter: U6
Reporter: eGFP (default), optional CFP, YFP, RFP, mCherry
Storage Buffer: PBS/5% Glycerol

Species: Mouse
Gene Symbol: Tnf
Gene Name: tumor necrosis factor
Gene ID: 21926
Gene Synonyms: DIF; TNF-a; TNF-alpha; Tnfa; TNFalpha; Tnfsf1a; TNFSF2; Tnlg1f
ORF Size: 708 bp
RefSeq#: NM_013693
Gene Description: Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation|Function: The TNF intracellular domain (ICD) form induces IL12 production in dendritic cells.
UniGene ID: Mm.1293