mouse TMEM173 shRNA silencing AAV

Cat. No: shAAV-274453

Availability: 4-5 weeks

Name: AAV-m-TMEM173-shRNA

This is an AAV expressing shRNA for silencing of Mouse Tmem173.

Request a Quote

Please enter your email address and we'll be in touch with more information:

Viral Backbone: Recombinant AAV
AAV-ITR: AAV2
AAV Serotype: Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
Promoter: U6
Reporter: eGFP (default), optional CFP, YFP, RFP, mCherry
Storage Buffer: PBS/5% Glycerol

Species: Mouse
Gene Symbol: Tmem173
Gene Name: transmembrane protein 173
Gene ID: 72512
Gene Synonyms: 2610307O08Rik; ERIS; Mita; MPYS; STING
ORF Size: 1137 bp
RefSeq#: NM_028261
Gene Description: Facilitator of innate immune signaling that promotes the production of type I interferon (IFN-alpha and IFN-beta). Innate immune response is triggered in response to non-CpG double-stranded DNA from viruses and bacteria delivered to the cytoplasm. Able to activate both NF-kappa-B and IRF3 transcription pathways to induce expression of type I interferon and exert a potent anti-viral state following expression. May be involved in translocon function, the translocon possibly being able to influence the induction of type I interferons. May be involved in transduction of apoptotic signals via its association with the major histocompatibility complex class II (MHC-II). Mediates death signaling via activation of the extracellular signal-regulated kinase (ERK) pathway.
UniGene ID: Mm.45995