mouse TEAD3 shRNA silencing AAV

Cat. No: shAAV-274007

Availability: 4-5 weeks

Name: AAV-m-TEAD3-shRNA

This is an AAV expressing shRNA for silencing of Mouse Tead3.

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Viral Backbone: Recombinant AAV
AAV-ITR: AAV2
AAV Serotype: Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
Promoter: U6
Reporter: eGFP (default), optional CFP, YFP, RFP, mCherry
Storage Buffer: PBS/5% Glycerol

Species: Mouse
Gene Symbol: Tead3
Gene Name: TEA domain family member 3
Gene ID: 21678
Gene Synonyms: DTEF-1; ETFR-1; Tcf13r2; TEAD-3; TEF-5
ORF Size: 1395 bp
RefSeq#: NM_011566
Gene Description: Transcription factor which plays a key role in the Hippo signaling pathway, a pathway involved in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein MST1/MST2, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Acts by mediating gene expression of YAP1 and WWTR1/TAZ, thereby regulating cell proliferation, migration and epithelial mesenchymal transition (EMT) induction. Binds to multiple functional elements of the human chorionic somatomammotropin-B gene enhancer.
UniGene ID: Mm.6655