mouse TCEB1 shRNA silencing AAV

Cat. No: shAAV-273902

Availability: 4-5 weeks

Name: AAV-m-TCEB1-shRNA

This is an AAV expressing shRNA for silencing of Mouse Eloc.

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Viral Backbone: Recombinant AAV
AAV-ITR: AAV2
AAV Serotype: Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
Promoter: U6
Reporter: eGFP (default), optional CFP, YFP, RFP, mCherry
Storage Buffer: PBS/5% Glycerol

Species: Mouse
Gene Symbol: Eloc
Gene Name: elongin C
Gene ID: 67923
Gene Synonyms: 2610043E24Rik; 2610301I15Rik; AA407206; AI987979; AW049146; Tceb1
ORF Size: 339 bp
RefSeq#: NM_026456
Gene Description: SIII, also known as elongin, is a general transcription elongation factor that increases the RNA polymerase II transcription elongation past template-encoded arresting sites. Subunit A is transcriptionally active and its transcription activity is strongly enhanced by binding to the dimeric complex of the SIII regulatory subunits B and C (elongin BC complex)|Function: The elongin BC complex seems to be involved as an adapter protein in the proteasomal degradation of target proteins via different E3 ubiquitin ligase complexes, including the von Hippel-Lindau ubiquitination complex CBC(VHL). By binding to BC-box motifs it seems to link target recruitment subunits, like VHL and members of the SOCS box family, to Cullin/RBX1 modules that activate E2 ubiquitination enzymes.
UniGene ID: Mm.289248