mouse SYTL2 shRNA silencing AAV

Cat. No: shAAV-273575

Availability: 4-5 weeks

Name: AAV-m-SYTL2-shRNA

This is an AAV expressing shRNA for silencing of Mouse SYTL2.

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Viral Backbone: Recombinant AAV
AAV-ITR: AAV2
AAV Serotype: Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
Promoter: U6
Reporter: eGFP (default), optional CFP, YFP, RFP, mCherry
Storage Buffer: PBS/5% Glycerol

Species: Mouse
Gene Symbol: SYTL2
Gene Name: synaptotagmin-like 2
Gene ID: 83671
Gene Synonyms: AI266830; mKIAA1597; Slp2
ORF Size: 2853 bp
RefSeq#: NM_031394
Gene Description: Isoform 1 acts as a RAB27A effector protein and plays a role in cytotoxic granule exocytosis in lymphocytes. It is required for cytotoxic granule docking at the immunologic synapse. Isoform 4 binds phosphatidylserine (PS) and phosphatidylinositol-4,5-bisphosphate (PIP2) and promotes the recruitment of glucagon-containing granules to the cell membrane in pancreatic alpha cells. Binding to PS is inhibited by Ca(2+) while binding to PIP2 is Ca(2+) insensitive.
UniGene ID: Mm.26751