mouse SMAD2 shRNA silencing AAV

Cat. No: shAAV-272599

Availability: 4-5 weeks

Name: AAV-m-SMAD2-shRNA

This is an AAV expressing shRNA for silencing of Mouse Smad2.

Request a Quote

Please enter your email address and we'll be in touch with more information:

Viral Backbone: Recombinant AAV
AAV-ITR: AAV2
AAV Serotype: Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
Promoter: U6
Reporter: eGFP (default), optional CFP, YFP, RFP, mCherry
Storage Buffer: PBS/5% Glycerol

Species: Mouse
Gene Symbol: Smad2
Gene Name: SMAD family member 2
Gene ID: 17126
Gene Synonyms: 7120426M23Rik; Madh2; Madr2; mMad2; Smad-2
ORF Size: 1404 bp
RefSeq#: NM_010754
Gene Description: Receptor-regulated SMAD (R-SMAD) that is an intracellular signal transducer and transcriptional modulator activated by TGF-beta (transforming growth factor) and activin type 1 receptor kinases. Binds the TRE element in the promoter region of many genes that are regulated by TGF-beta and, on formation of the SMAD2/SMAD4 complex, activates transcription. May act as a tumor suppressor in colorectal carcinoma. Positively regulates PDPK1 kinase activity by stimulating its dissociation from the 14-3-3 protein YWHAQ which acts as a negative regulator.
UniGene ID: Mm.391091