mouse SIRT5 shRNA silencing AAV

Cat. No: shAAV-272011

Availability: 6-8 weeks

Name: AAV-m-SIRT5-shRNA

This is an AAV expressing shRNA for silencing of Mouse Sirt5.

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Knockdown: shRNA screening service available, please inquire about this service or other options.

Viral Backbone: Recombinant AAV
AAV-ITR: AAV2
AAV Serotype: Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
Promoter: U6
Reporter: eGFP (default), optional CFP, YFP, RFP, mCherry
Storage Buffer: PBS/5% Glycerol

Species: Mouse
Gene Symbol: Sirt5
Gene Name: sirtuin 5
Gene ID: 68346
Gene Synonyms: 0610012J09Rik; 1500032M05Rik; AV001953
ORF Size: 567 bp
RefSeq#: NM_178848
Gene Description: NAD-dependent lysine demalonylase and desuccinylase that specifically removes malonyl and succinyl groups on target proteins. Activates CPS1 and contributes to the regulation of blood ammonia levels during prolonged fasting: acts by mediating desuccinylation of CPS1, thereby increasing CPS1 activity in response to elevated NAD levels during fasting. Has weak NAD-dependent protein deacetylase activity; however this activity may not be physiologically relevant in vivo. Can deacetylate cytochrome c (CYCS) and a number of other proteins in vitro.
UniGene ID: Mm.35325