mouse SCRIB shRNA silencing AAV

Cat. No: shAAV-271471

Availability: 4-5 weeks

Name: AAV-m-SCRIB-shRNA

This is an AAV expressing shRNA for silencing of Mouse Scrib.

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Viral Backbone: Recombinant AAV
AAV-ITR: AAV2
AAV Serotype: Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
Promoter: U6
Reporter: eGFP (default), optional CFP, YFP, RFP, mCherry
Storage Buffer: PBS/5% Glycerol

Species: Mouse
Gene Symbol: Scrib
Gene Name: scribbled planar cell polarity
Gene ID: 105782
Gene Synonyms: AI118201; Crc; CRIB; mKIAA0147; Scrb1; SCRIB1; vartul
ORF Size: 4839 bp
RefSeq#: NM_134089
Gene Description: Scaffold protein involved in different aspects of polarized cells differentiation regulating epithelial and neuronal morphogenesis. Most probably functions in the establishment of apico-basal cell polarity. May function in cell proliferation regulating progression from G1 to S phase and as a positive regulator of apoptosis for instance during acinar morphogenesis of the mammary epithelium. May also function in cell migration and adhesion and hence regulate cell invasion through MAPK signaling. May play a role in exocytosis and in the targeting synaptic vesicles to synapses. Functions as an activator of Rac GTPase activity.
UniGene ID: Mm.25568