mouse SARM1 shRNA silencing AAV

Cat. No: shAAV-271364

Availability: 6-8 weeks

Name: AAV-m-SARM1-shRNA

This is an AAV expressing shRNA for silencing of Mouse Sarm1.

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Knockdown: shRNA screening service available, please inquire about this service or other options.

Viral Backbone: Recombinant AAV
AAV-ITR: AAV2
AAV Serotype: Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
Promoter: U6
Reporter: eGFP (default), optional CFP, YFP, RFP, mCherry
Storage Buffer: PBS/5% Glycerol

Species: Mouse
Gene Symbol: Sarm1
Gene Name: sterile alpha and HEAT/Armadillo motif containing 1
Gene ID: 237868
Gene Synonyms: A830091I15Rik; C78606; MyD885; Sarm
ORF Size: 2175 bp
RefSeq#: NM_172795
Gene Description: Involved in innate immnune response. Acts as a negative regulator of TICAM1/TRIF-dependent Toll-like receptor signaling by inhibiting induction of TLR3- and TLR4-dependent genes. Specifically blocks TICAM1/TRIF-dependent transcription-factor activation and gene induction, without affecting the MYD88-dependent pathway or non-TLR signaling. Negative regulator of NF-kappa-B and IRF activation.
UniGene ID: Mm.210332