mouse RPE65 shRNA silencing AAV

Cat. No: shAAV-270828

Availability: 6-8 weeks

Name: AAV-m-RPE65-shRNA

This is an AAV expressing shRNA for silencing of Mouse Rpe65.

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Knockdown: shRNA screening service available, please inquire about this service or other options.

Viral Backbone: Recombinant AAV
AAV-ITR: AAV2
AAV Serotype: Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
Promoter: U6
Reporter: eGFP (default), optional CFP, YFP, RFP, mCherry
Storage Buffer: PBS/5% Glycerol

Species: Mouse
Gene Symbol: Rpe65
Gene Name: retinal pigment epithelium 65
Gene ID: 19892
Gene Synonyms: 65kDa; A930029L06Rik; LCA2; Mord1; rd12; RP20
ORF Size: 1602 bp
RefSeq#: NM_029987
Gene Description: Plays important roles in the production of 11-cis retinal and in visual pigment regeneration. The soluble form binds vitamin A (all-trans-retinol), making it available for LRAT processing to all-trans-retinyl ester. The membrane form, palmitoylated by LRAT, binds all-trans-retinyl esters, making them available for IMH (isomerohydrolase) processing to all-cis-retinol. The soluble form is regenerated by transferring its palmitoyl groups onto 11-cis-retinol, a reaction catalyzed by LRAT. The enzymatic activity is linearly dependent of the expression levels and membrane association.
UniGene ID: Mm.131708