mouse PTGDS shRNA silencing AAV

Cat. No: shAAV-269734

Availability: 4-5 weeks

Name: AAV-m-PTGDS-shRNA

This is an AAV expressing shRNA for silencing of Mouse Ptgds.

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Viral Backbone: Recombinant AAV
AAV-ITR: AAV2
AAV Serotype: Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
Promoter: U6
Reporter: eGFP (default), optional CFP, YFP, RFP, mCherry
Storage Buffer: PBS/5% Glycerol

Species: Mouse
Gene Symbol: Ptgds
Gene Name: prostaglandin D2 synthase (brain)
Gene ID: 19215
Gene Synonyms: 21kDa; L-PGDS; PGD2; PGDS; PGDS2; Ptgs3
ORF Size: 570 bp
RefSeq#: NM_008963
Gene Description: Catalyzes the conversion of PGH2 to PGD2, a prostaglandin involved in smooth muscle contraction/relaxation and a potent inhibitor of platelet aggregation. Involved in a variety of CNS functions, such as sedation, NREM sleep and PGE2-induced allodynia, and may have an anti-apoptotic role in oligodendrocytes. Binds small non-substrate lipophilic molecules, including biliverdin, bilirubin, retinal, retinoic acid and thyroid hormone, and may act as a scavenger for harmful hydrophopic molecules and as a secretory retinoid and thyroid hormone transporter. Possibly involved in development and maintenance of the blood-brain, blood-retina, blood-aqueous humor and blood-testis barrier. It is likely to play important roles in both maturation and maintenance of the central nervous system and male reproductive system.
UniGene ID: Mm.1008