mouse PSME3 shRNA silencing AAV

Cat. No: shAAV-269686

Availability: 4-5 weeks

Name: AAV-m-PSME3-shRNA

This is an AAV expressing shRNA for silencing of Mouse Psme3.

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Viral Backbone: Recombinant AAV
AAV-ITR: AAV2
AAV Serotype: Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
Promoter: U6
Reporter: eGFP (default), optional CFP, YFP, RFP, mCherry
Storage Buffer: PBS/5% Glycerol

Species: Mouse
Gene Symbol: Psme3
Gene Name: proteaseome (prosome, macropain) activator subunit 3 (PA28 gamma, Ki)
Gene ID: 19192
Gene Synonyms: AA410043; AU020960; Ki; pa28g; PA28gamma; REGgamma
ORF Size: 765 bp
RefSeq#: NM_011192
Gene Description: Subunit of the 11S REG-gamma (also called PA28-gamma) proteasome regulator, a doughnut-shaped homoheptamer which associates with the proteasome. 11S REG-gamma activates the trypsin-like catalytic subunit of the proteasome but inhibits the chymotrypsin-like and postglutamyl-preferring (PGPH) subunits. Facilitates the MDM2-p53/TP53 interaction which promotes ubiquitination- and MDM2-dependent proteasomal degradation of p53/TP53, limiting its accumulation and resulting in inhibited apoptosis after DNA damage. May also be involved in cell cycle regulation.
UniGene ID: Mm.288477