mouse OPA1 shRNA silencing AAV

Cat. No: shAAV-267654

Availability: 4-5 weeks

Name: AAV-m-OPA1-shRNA

This is an AAV expressing shRNA for silencing of Mouse Opa1.

Request a Quote

Please enter your email address and we'll be in touch with more information:

Viral Backbone: Recombinant AAV
AAV-ITR: AAV2
AAV Serotype: Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
Promoter: U6
Reporter: eGFP (default), optional CFP, YFP, RFP, mCherry
Storage Buffer: PBS/5% Glycerol

Species: Mouse
Gene Symbol: Opa1
Gene Name: optic atrophy 1
Gene ID: 74143
Gene Synonyms: 1200011N24Rik; AI225888; AI847218; lilr3; mKIAA0567
ORF Size: 2883 bp
RefSeq#: NM_133752
Gene Description: Dynamin-related GTPase required for mitochondrial fusion and regulation of apoptosis. May form a diffusion barrier for proteins stored in mitochondrial cristae. Proteolytic processing in response to intrinsic apoptotic signals may lead to disassembly of OPA1 oligomers and release of the caspase activator cytochrome C (CYCS) into the mitochondrial intermembrane space|Function: Dynamin-like 120 kDa protein, form S1: Inactive form produced by cleavage at S1 position by OMA1 following stress conditions that induce loss of mitochondrial membrane potential, leading to negative regulation of mitochondrial fusion.
UniGene ID: Mm.274285