mouse OMA1 shRNA silencing AAV

Cat. No: shAAV-267639

Availability: 4-5 weeks

Name: AAV-m-OMA1-shRNA

This is an AAV expressing shRNA for silencing of Mouse Oma1.

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Viral Backbone: Recombinant AAV
AAV-ITR: AAV2
AAV Serotype: Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
Promoter: U6
Reporter: eGFP (default), optional CFP, YFP, RFP, mCherry
Storage Buffer: PBS/5% Glycerol

Species: Mouse
Gene Symbol: Oma1
Gene Name: OMA1 zinc metallopeptidase
Gene ID: 67013
Gene Synonyms: 2010001O09Rik; MPRP-1; ZMPOMA1
ORF Size: 1566 bp
RefSeq#: NM_025909
Gene Description: Metalloprotease that is part of the quality control system in the inner membrane of mitochondria. Following stress conditions that induce loss of mitochondrial membrane potential, mediates cleavage of OPA1 at S1 position, leading to OPA1 inactivation and negative regulation of mitochondrial fusion. Its role in mitochondrial quality control is essential for regulating lipid metabolism as well as to maintain body temperature and energy expenditure under cold-stress conditions.
UniGene ID: Mm.30021